1575 / 1674
Darby et al., NEJM, 2013.
Rates of major coronary events increased linearly with
the
mean dose to the heart
by 7.4% per gray with no apparent threshold.
Lee at al. Am J Cardiol, 2013.
Patients with left-sided breast cancer treated with
radiotherapy have a higher risk of severe stenosis involving the mid and distal
left
anterior descending
arteries and the distal diagonal branches.
LAD artery dose
≈
maximum dose to small volume
Dose to the heart