850 / 1674
Cosmetic outcome ELIOT
Overall, side effects showed a significant difference in
favour of the ELIOT arm (p=0.0002)
Few skin side effects in the ELIOT arm, skin being excluded from the target,
erythema (p<0.0001)
dryness (p=0.04)
hyper-pigmentation (p=0.0004)
pruritus (p=0.002)
No differences were observed for mammary fibrosis, mammary retraction, pain or
burning
A higher incidence of fat necrosis was observed in the ELIOT arm with an incidence
of
12% (p<0.04).
A subgroup of 178 volunteers (95 from the ELIOT arm and 83 from the external RT
arm) accepted to undergo a follow-up spiral CT-scan:
Pulmonary fibrosis was diagnosed in 42 (23.6%) of the patients examined
4 (10%) had received ELIOT
38 (90%) external RT (p <0.0001).
Twenty-six of these were grade 1 (1 in the ELIOT arm), 15 grade 2 (3 in the ELIOT
arm) and one was grade 3 in the external RT arm.
Courtesy R. Orrechia