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Inter-/intrafraction variation in cervix
cancer BT
# patients treatment
fractions
time range
Image type
images
variation
1
21
HDR
4
18-20 hrs
MRI
84
Intra-app.
2
21
HDR
3
5 hrs
MRI
72
Intra-app.
3
9
PDR
2 x 29 / 32
22 hrs
MRI
36
Intra-app.
4
14
HDR
5
1-22 days
CT
69
Inter-app.
5
27
HDR
4
7-10 days
MRI
54
Inter-app.
6
31
PDR
2 x 20
1 week
MRI
62
Inter-app.
123 patients
5 h – 3 weeks
377 3 + 3
Nesvacil et al. 2013, Radiother Oncol 107
© Lang et al. 2013, Radiother Oncol 107
Klug F1
Klug F2
fraction 1
fraction 2
fraction 3
fraction 4
1 plan evaluated for images at different time points.
Anatomical changes between irradiations may lead to large random dosimetric uncertainties
Inter-/intrafraction variation in cervix cancer BT