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Consequences:
Uncertainties associated with this process?
•
Limited measurements
➢
e.g. 1930s’ data of prostate from a specimen of 14 year old boy
1
•
Considerable tissue composition variability
➢
e.g. Adipose tissue water content between 23% to 78%
2
•
Patient-specific distribution of tissue types
➢
e.g. Breast adipose vs glandular composition: 16% to 68%
3,4
1) A. H. Neufeld, Canadian Journal of Research 15B, 132-138 (1937).
2) B. Brooksby, B. W. et al., PNAS 103 (23), 8828-8833 (2006).
3) R. A. Geise and A. Palchevsky, Radiology 198 (2), 347-50 (1996)
4) The Myth of the 50-50 breast, MJ Yaffe et al., Med Phys 36 (2009)