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LQ Model
Biological effect E of dose D:
Total dose :
n... Nr. of fractions, d... fraction dose
=
E =
a
x
total dose
x
relative dose effectiveness
Biologically effective dose:
BED = total dose x relative dose effectiveness = E /
a
2
D D E
+ =
b
a
dn
D
=
)
/
1(
)
(
)
(
2
b
a
a
b
a
b
a
d
nd
d
nd
d d nE
+ =
= + = + =