1097 / 1851
Total dose
p value
p value
8 Gy
0.69 (0.35-1.37)
NS
0.76 (0.28-2.10)
0.02
24-25 Gy
0.88 (0.75-1.04)
0.52 (0.41-0.67)
30 Gy
0.81 (0.59-1.12)
0.34 (0.19-0.59)
36-40 Gy
0.81 (o.54-1.20)
0.27 (0.14-0.51)
Timing
(between start of induction CT and randomization to PCI)
< 4 mo
0.92 (0.66-1.29)
NS
0.27 (0.16-0.46)
0.01
4-6 mo
0.79 (0.61-1.02)
0.50 (0.35-0.72)
> 6 mo
1.01 (0.74-1.38)
0.69 (0.44-1.08)
Relative risk
of death (95% CI)
Meta-analysis of PCI in SCLC : RT doses
Relative risk
of brain mets (95% CI)
Auperin A. et al. NEJM 1999;341