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Summary
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What we can’t do
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8000 pt trials in unselected breast cancer
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What we can do –
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New continuum for genome-forward approaches
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Representative model systems in parallel +
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Small hypothesis-driven trials
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New strategies for biomarker-driven clinical trials
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Start broadly (relatively unselected) and learn
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Be as critical about assays as you are of drugs
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Novel strategies are good, but so are traditional endpoints –
Overall survival
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Embrace your lab colleagues, molecular pathologists, and
statisticians!