1226 / 1851
03/01/13
RT alone
RT + cetuximab
p
- value
Mucositis (grade 3-5)
52%
56%
N.S.
Skin rash (all grades)
10%
87%
< 0.001
Radiation dermatitis (grade 3-5)
18%
23%
N.S.
Weight loss (all grades)
72%
84%
0.005
Nausea (all grades)
37%
49%
0.02
Fever (all grades)
13%
26%
0.001
Anemia (all grades)
13%
3%
< 0.001
Acute toxic effects (WHO criteria)
Late toxicity: no difference
Radiotherapy ± EGFR-I
Bonner JA 2010