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Histologic Grade
Low ( I of III)
Intermediate (II of III)
High (III of III)
Biomarkers
ER expression
+++
++ to +++
+ to ++
PR expression
++ to +++
0 to +++
0 to ++
Proliferation
(Ki-67 /
S phase fraction)
Low
(<10%)
Intermediate
(10-20%)
High
(>20%)
HER2 Overexpression
Never
Occasional
Occasional
Genetic / Genomic /
multipanel markers
21-gene recurrence
score
Low
(< 18)
Intermediate
(18-25)
High
( >25)
Intrinsic subtype
Genomic Grade
Lower
Higher
IHC4
Lower
Higher risk
MammaPrint
Low
High
Tumor DNA ploidy
Mostly diploid
Mostly aneuploid
Luminal A
Luminal B
Integrate pathology and biology
St Gallen 2017
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