![Show Menu](styles/mobile-menu.png)
![Page Background](./../common/page-substrates/page1262.jpg)
Disease Free Survival
Definition Time from randomisation to recurrence (in
ITT population)
Pros
•
Smaller population and shorter follow-up
•
Not affected by crossover or subsequent
treatment (eg checkpoint inhibitors)
Cons
•
? Measure of direct benefit
•
Subject to assessment bias
•
Unreliable and imprecise timing
•
Need to balance radiological assessments ie
need standardized follow-up protocols
Censor
bias – if imbalanced withdrawal of patients who are
censored prior to relapse or progression