1356 / 1851
75
50
25
0
Percentage of patients
having a local relapse (%)
0 2
4 6
8 10 12 14 16 18 20
Time since randomisation (years)
RT alone
CMT
HR 0.46, p<0.001
ACT I :Time to first local relapse
Northover J et al Br J Cancer 2010;102(7):1123–8