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HAZARD RATIOS
•
OS, DFS and PFS report difference between
experimental/control curves as Hazard Ratio (HR).
i.e. ratio between events occurring in any given time
interval with experimental compared to control treatment
is constant
•
HR may not be meaningful if survival curves are not of
similar shape
•
If HR <1 and the 95% confidence interval excludes 1,
there is a statistically significant effect of the
experimental treatment as compared to control.