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Take Home Message (DLBCL)

The development of tailored therapy according to the relapse risk

is warranted, rather than uniform treatment of all early-stage

DLCL (bulky disease, PET-oriented treatment)

Therapeutic burden: R-CHOP x 3 cycles followed by 30 Gy IF-RT

probably better than R-CHOP x 6 cycles (less toxic and probably

higher survival rates)

Consolidative RT is strongly recommended, even after 6 R-CHOP

and in advanced stage DLBCL, for patients with bulky lesions or

skeletal involvement