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Chemotherapy
YES
NO
High grade
High Ki67
Low ER and PR
High genomic risk
Luminal B like
Risk of early recurrence
Low grade
Low Ki67
High ER e PR
Low genomic risk
Luminal A or surrogate
Risk of late recurrence
M
A
Y
B
E
Stage of disease
Limited indication to
chemotherapy
Consider:
Patient preference
Comorbidity
Consider chemotherapy
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