Diapositive 1

Systemic treatment

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Indication – extrapolate from histology (breast adenoCa)

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N+, LVSI+ - in breast Ca, would offer systemic treatment

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What systemic treatment?

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Consider therapeutic indices AND economic cost

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ER positive - give tamoxifen (benefit U/K, toxicity low,

cost low)

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HER-2 positive – do not give Herceptin (benefit U/K,

toxicity high, cost very high)

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Chemo - ??? (benefit U/K, toxicity high, cost high)