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Clin Cancer Research July 2015 Volume 21, Issue 14
Function:
On T reg:
Reduction of T regs
infiltration
On NK
Enhanced ADCC (antibody-dependent cell-
mediated cytotoxicity)
On DC
Enhancing co-stimulation
On T cells increasing:
proliferation, resistance to apoptosis, IFNγ secretion
increase in tumor-selective cytolytic T-cell activity
CD137: CD137L