1832 / 1851
Toxicity of concurrent SRT and
tyrosine kinase inhibitors (TKIs)
Multi receptor TKIs (sorafenib, sunitinib)
Cranial SRT
+ sorafenib or sunitinib: safe
but one grade 5
toxicity has been observed for sunitinib.
For extra-cranial SRT, liver SRT combined with
sorafenib is
associated with severe toxicity
No radiation induced toxicity sunitinib and extra-cranial SRT.
Kroeze S et al. Cancer Treatment Reviews 53 (2017) 25–37