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d-HER2 induces antibodies that specifically
bind the native HER2 receptor
•
The ECD binding ratio seems to increase with the
dose of HER2 protein when assessed after the
administration of four dHER2 + AS15 doses.
Day 0
Day 56
SKBR3
Day 0
Day 56
BT474
Cohort 1 Cohort 2 Cohort 3 Cohort 4
%
0
20
40
60
80
100
A
B
C
G. Curigliano et al. 2016