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5FU/CDDP

±

Cetuximab:

SCOPE Trial

Phase II/III trial:

RT-CT: Cisplatin 60 mg/m2 D1+ capecitabine: 625mg/m2 twice daily

4 cycles – RT 50 Gy during cycles 3&4

±

Cetuximab: 400 mg/m2 D1 then 250 mg/m2 weekly

Crosby, Lancet Oncol 2013; 14: 627–37