345 / 1851
Skladowski al. 2000.
CAIR: Continuous accelerated fractionation
Conventional
100 pts.
Loco-regional control
CAIR
5 vs 7 Fx / week (66-70 Gy/ 33-35 fx)
LATE REACTIONS
0
10
20
30
40
50
GRADE 3-4 COMPLICATIONS (%)
7 fx wk
1.8 Gy
7 fx wk
2.0 Gy
5 fx wk
2.0 Gy
82%
37%
P<0.001