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DNA repair
• RT-induced cell damage activate repair
- Increased PI3-K and DNA-PK
- EGFR enters nucleus bound to KU70/80 and increases
DNA-DNA-PK complex and repair
• EGFR-I inhibits EGFR enucleation
• Interaction between EGFR-I bound
to EGFR and DNA-PK increases
sequestration of DNA-PK
Lieber 1999; Dittmann K 2000 etc..