742 / 1851
Incidence and risk factors
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Rare disease
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Annual incidence: 1-2/100 000 (USA)
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Incidence is increasing over the last 25 years
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5 year survival: +/- 60%
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Risk factors:
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HPV (in 90% of the patients), HIV, (HSV)
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Immune suppression (transplant recipients)
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Cigarette smoking
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Previous malignancies
(gynaecological, lymphoma, leukemia)