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Trial

N of

patients

IMRT Regimen

Toxicity Efficacy

Feliu et al,

ASCO 2014

GEMCAD 09-02

58

No

45 Gy

+ boost of

10-15 Gy

5-FU/MMC

+RT +

panitumumab

High

33/36

(92%)

G3/4 AE

At 24

weeks 55%

had CR

Tri

als with Panitumumab/RT in anal cancer