924 / 1851
0
100
200
300
400
500
600
700
800
0
10
20
30
40
50
tumor volume mm3
control
control
PTK RT
combined
Treatment
0
100
200
300
400
500
600
700
800
0
10
20
30
40
50
days after treatment start
tumor volume mm3
PTK
RT
combined
Treatment
Relevance of Immune System for Treatment Response
Minimal Treatment Schedule:
4 x 3 Gy + 4 x 100 mg/kg PTK787
Tumor in
immune compromised mice
Tumor in
immune-competent mice
Riesterer et al., 2007, 2011