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True RT-induced abscopal effects exist, are rare, are immune-
mediated (irradiated tumor as immunogenic hub)
Novel immunomodulatory agents have the potential to
maximise RT-induced anti-tumor immune responses
Radiotherapy can enhance antitumor immune response
Multiple questions exist:
Relation between dose/fraction and the immune effects of
radiation; additional resistance mechanisms
Timing of immune therapy with radiotherapy is crucial
Summary
Is
R
ejection of neoplastic lesions by immune system a novel «
R
»?