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Santana-Davila R, et al, JCO, 2015;33
Cisplatin + Etoposide vs Carboplatin + Paclitaxel
:
NO OS DIFFERENCE but INCREASE TOXICITY wit Cisplatin + Etoposide
OS in Overall Population
OS after propensity score
Patients treated with Cisplatin + Etoposide had:
More hospitalizations (p <0.001)
Infectious complications (p = 0.002)
Acute kidney disease (p < 0.001)
Mucositis/esophagitis (p = 0.02)