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FOR EXPERT REVIEW PANEL USE ONLY

NOT FOR DISTRIBUTION

1

Expert Review Panel for Infant Formula and Adult Nutrition

Evaluation of Method:

Chlor-03/Fluor-02 #

3

Title:

Ion Chromatography method for the determination of Fluoride and Chloride in Infant Formula and Adult

Nutritionals

Author:

Thermofisher

Summary of Method:

Ultra-centrifugation is used to filter the sample and remove the fats and proteins from the sample.

Following the filtration, solution was passed through cation exchange cartridge to remove heavy metals

(such as Iron) from the samples. Samples were then separated using an anion-exchange column and

detected by suppressed conductivity.

Method Scope/Applicability:

Infant Formula and Adult/Pediatric Formulas

General comments about the method:

Method Clarity:

Clear directions for operation of the method, instruments. Clear equations describing how the standards

and samples are quantitated is required.

Method Safety Concerns:

None other than standard laboratory safety

Pros/Strengths:

Very simple straightforward analysis.

Cons/Weaknesses

Unclear as to whether only Thermofisher columns and cartridges are required or if alternatives are

available.

Supporting Data

SPIFAN kit has been used for both fluoride and chloride validation.

Performance Characteristics:

Analytical Range:

4-800 μg/100g fluoride, meets SMPR

4-2400 μg/100g chloride, meets SMPR

Chlor-03/Fluor-02 Review Forms