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From 2D to 3D Dose-Volume Analysis
“There is a lack of correlation between conventional IMRT QA
performance metrics (Gamma passing rates) and dose errors in anatomic
regions-of-interest. The most common acceptance criteria and published
actions levels therefore have insufficient, or at least unproven, predictive
power for per-patient IMRT QA.”*
To 3D using 2D measurements
Mathematically perturb the dose in the patient
Reconstruct the dose in the phantom
Recalculate dose in the patient based on the reconstructed fluence
*Nelms BE, Zhen H, Tomé WA. Per-beam, planar IMRT QA passing rates do not predict clinically relevant
patient dose errors. Med Phys. 2011 Feb;38(2):1037-44.