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HDR vs. LDR in prostate cancer
Randomised trial of external beam radiotherapy
alone or combined with high-dose-rate
brachytherapy boost for localised prostate cancer
Peter J. Hoskin et al. RO 2012; 103(2):217-22.
May be radiobiological advantage of
HDR over LDR if prostate α/β ratio is
low
HDR Equipment already available in
most departments and less costly
HDR may have fewer issues with QA:
mis-placement of LDR seeds results in
poor quality implants
Toxicity profile may be more favourable
(shorter duration)