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95%

ICRU-50

planned dose

blurred dose

CTV

2.5Σ

1.64√(σ

2

p

2

)-1.64σ

p

Add random errors

M

PTV

= 2.5Σ + 0.7σ

Gauss(√(σ

p

2

+ σ

2

))

Fluence

Gauss(σ

p

)

Fluence

Water: σ

p

3.2 mm

PTV