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Final remarks
this is not more than an introduction, see Bibliography for further
reading
important ommission: how to deal with tumor deformations
establish Σ(
j
) and σ(
j
) for various parts
j
of the tumor and use
M(j)=2.5Σ
(j
)
+0.7
σ(
j
)
Monte Carlo simulations including models for non-rigid motion
derived for multiple CT-scans per patients: Mutanga et al 2012
If tumor moves then also surroundig tissues move: omit margins and
incorporate motion distributions for tumor and OAR in cost functions
for IMRT optimization (robust planning)
IT ALL STARTS WITH MEASURING ERRORS!!!