694 / 1542
SRS with or without WBRT in the treatment of patients with single of multiple brain metastases
Randomized trials # BM Study endpoint
SRS
SRS+WBRT
p
Aoyama
JAMA 2006
1-4 MS (months)
8
7.5
NS
1 year overall recurrence rate
76.4%
46.8% <0.001
Neurological death rate
19.3%
22.8%
NS
1y KPS > 70
27%
34%
NS
EORTC 22952-26001
Kocher JCO 2011
1-3 Median OS (months)
10.7
10.9
NS
2y relapse at initial site
31%
19%
0.04
2y relapse at new intracranial site
48%
33%
0.02
2y Survival with functional
independance
22.3%
22.6%
NS
27
Brain metastasis
Clinical indications
Radiosurgery +/- whole brain radiotherapy