705 / 1542
Study
Pts/
targets
Dose
Grade 3
hepatic
toxicity
Herfarth
JCO 2001
37/60 14-26 Gy/ 1fr
0
Kavanagh
Acta Oncol 2006
21/28 36-60 Gy / 3fr
0
Mendez-Romero
Acta Oncol 2006
17/34 37.5 Gy / 3 fr
2 pts
Katz
IJROBP 2007
69/174 50 Gy / 5fr
0
Rusthoven
JCO 2009
47/63 36-60 Gy / 3fr
1 pt
Lee
JCO 2009
68/141 27.7-60 Gy / 6 fr
2 pts
Van der Pool
Br J Surg 2010
20/31 37.5-45 Gy / 3 fr
2 pts
Typical acute toxicity:
-Fatigue
-Nausea
-Abdominal pain
-Fever
-Liver enzymes
-Erythema
-Gastritis/oesophagitis/colitis
Rare severe toxicity:
-RILD
-Liver function decline
-GI ulceration
-GI perforation
Liver metastasis: toxicity
Clinical indications
38