1191 / 1694
HYBRID study
Hy
pofractionated
B
ladder
R
adiotherapy with or without
I
mage
guided a
D
aptive planning
•
A multicentre randomised phase II study (36Gy in 6f)
29
Group 1:
Standard planning (control)
Planning CT scan post void. Clinical target volume
(CTV): whole bladder plus any area of extravesical
spread.
One 3D conformal plan will be generated with 1.5cm
expansion margin.
Pre-treatment Cone Beam CT will be used to verify CTV
coverage.
Group 2:
Adaptive planning (experimental)
Planning CT scan post void. CTV: whole bladder plus
any area of extravesical spread.
Three 3D conformal plans will be generated:
1. Small; 2. Medium; 3. Large
Pre-treatment Cone Beam CT will be used to select
appropriate plan, this will be confirmed by a second
trained observer.
RANDOMISE
1:1
Chief Investigator Prof Robert Huddart