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Radiotherapy in breast cancer: Heart Toxicity
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Latency of 15-20 years
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Myocardial scintigraphy can detect perfusion changes as early as 6 mo
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Target structures:
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Myocardium (e.g. left ventricle)
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Vessels (e.g. left anterior descending coronary artery)
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Toxicity
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Myocardial infarction
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Angina
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CHF
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Valvular disorders
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Electrical conductivity alterations
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Dose threshold??
03/01/13