1067 / 1068
ADXS11-001 immunotherapy
•
live attenuated Listeria monocytogenes (Lm)
•
bioengineered to secrete a HPV-16-E7 fusion protein
targeting HPV transformed cells.
•
Anal cancer cells infected with HPV have the tumour
associated antigen HPV E7.
•
So ADXS11-001 causes antigen presenting cells to be
stimulated to facilitate immune cells to attach to cancer cells
expressing HPV E7
•
neutralizes Tregs and myeloid-derived suppressor cells
(MDSCs), which protect the tumour microenvironment
from immunologic recognition and contribute to tumour
growth
.