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Conclusions (I)

What have we learned?

Sequence RT, Chemo, S matters

(CAO/ARO/AIO-94)

Synergy RT – 5-FU Chemo

(FFCD 9303, EORTC 22921)

RT - optimized S complementary

(Dutch Trial, MRC CR07)

Interval between RT + S matters

(TIMING; Stockholm III)

Compliance RT + Chemo matters

(CAO/ARO/AIO-04)