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Late SB Toxicity: pathogenesis and symptoms
DAMAGE
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Vascular degeneration (endoarteritis)
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Collagen production/deposition
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Damage of the lymphatic vessels
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Ischemia
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Intestinal wall edema
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Mucosal ulcer
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Intestinal wall necrosis
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Hemorrages
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Strictures/Stenosis
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Adherences
SYMPTOMS
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Intestinal transit alterations: PAIN and CRAMPS
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Alternating STIPSIS and DIARRHEA
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Maladsorption syndrome, FOOD INTOLEREANCE
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Bleeding and anemia
Sub-mucosal fibrosis, atipical fibrobasts, inflammatory infiltration,
increased size of the endotelial cells