761 / 1068
US Prospect Alliance
Intergroup phase III trial
ACOSOG, Z9062, CALGB, E81001
R
FOLFOX #6
5FU CRT
T
M
E
FOLFOX #8
FOLFOX #6
R0?
PR/SD
?
LARC
st II/III
MRI:
CRM -ve
R1/2?
PD?
5FU CRT
5FU CRT
N planned: 1010
1
°
endpoint: 3y DFS
2
°
toxicity, local failures, OS,