821 / 1068
0.3
0.2
P
=0.006
Locoregional Recurrences
Pre- vs post-operative chemoradiation
CAO/ARO/AIO-94
Acute G3/4 adverse events
27% vs 40% (p=0.001)
Long-term G3/4
0.0
0.1
0
24
12
48
36
60
Months
Post
Pre
13%
6%
adverse events
14% vs 24% (p=0.01)
Sauer R. et al., N Engl J Med 2004;351: 1731-39
There is a
standard for
chemoradiation