840 / 1068
5-FU = Cape in Pre-op Rectal Cancer:
NSABP R-04
Capecitabine
(825 mg BID)
50.4 Gy
+
Oxaliplatin
(50 mg/m2 qw
)
Stratify
• T2 vs. T3
+
Oxaliplatin
(50 mg/m2 qw)
• M vs. F
• SP vs. APR
CI 5-FU
(225 mg/m2/d)
50.4 Gy
R
n=1608
NSABP R-04, Allegra et al; ASCO GI
2014