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Evidence in order of strength

Specific randomised trials (

Quasar

, EORTC 22921,

Sainato,

SCRIPT

, Chronicle, ADORE)

Composite trials (PETACC-6 and German trial)

Individual patient Meta-analyses (often selected –

some used retrospective data)

Pooled analyses

Systematic reviews

Nomograms based on randomised trials -Valentini

SCPRT 5x5Gy in Red