Microsoft PowerPoint - L00 Introduction

Bone marrow

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RT-CT ≈

60% Haematological Toxicity (HT)

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Dose constraints:

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Iliac crests: V50< 5%, V40 <35%, V30 < 50%

(RTOG 0529 G3+ HT 57%)

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Bone marrow in the flat bones

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≈ 50% in the pelvis

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Red BM (active); Yellow BM (inactive)

Kachnich LA et al Int J Radiat Oncol Biol Phys 2012