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Anal Cancer : the importance of
tumour size
•
Das et al ( 2007 ) : 167 patients treated with CRT
3 yr locoregional control :
T1/Tx 90 % ( 76 – 100 )
T2 86 % ( 76 – 96 )
T3 77 % ( 61 – 93 )
T4 63 % ( 41 – 86 )
T stage a significant independent
predictor of loco-regional failure
on multivariate analysis ( HR 1.71 )
•
Ajani et al ( 2009 & 2010 ) : RTOG 98-11 trial of RT +
5FU/MMC versus RT + 5FU/cisplatin
•
Tumour diameter > 5cm associated with a greater risk of
colostomy, worse 5 yr DFS & 5 yr OS ( p = 0.0003 ) compared
with smaller tumours