34 / 88
5
Docket No. 50229-337, filed as a US Provisional Patent Application, No. 60, XXX,
XXX, July 23
rd
, 2003.
3. Stinchcomb, Audra; Crook, Peter
; Hamad, Mohamed
. Enhancing transdermal
delivery of opiate antagonsts and agonists using codrugs linked to bupropion and
hydroxybupropion. UK Disclosure No. 1426, July 253
th
, 2006.
PUBLICATIONS:
4. Kiptoo, Paul K.; Paudel, Kalpana S.; Hammell, Dana C.;
Hamad, Mohamed O
.; ; Crooks,
Peter A. Stinchcomb, Audra L. In vivo evaluation of transdermal codrug of 6-β-naltrexol
linked to hydroxybupropion in hairless guinea pigs. Eur. J. Pharm. Sc. 2008 April, 33(4-
5), 371379
5.
Hamad, Mohamed O
.; Kiptoo, Paul K.; Stinchcomb, Audra L.; Crooks, Peter A.
Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6-β-
naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents.
Bioorganic & Medicinal Chemistry, 2006, 14(20), 7051-7061.
6. Kiptoo, Paul K.;
Hamad, Mohamed O
.; Crooks, Peter A.; Stinchcomb, Audra L.
Enhancement of transdermal delivery of 6-β-naltrexol via a codrug linked to
hydroxybupropion. Journal of Controlled Release, 2006, 13(2), 137-145.
7. Valiveti, Satyanarayana; Paudel, Kalpana S.; Hammell, Dana C
.; Hamad, Mohamed O
.;
Chen, Jianhong; Crooks, Peter A.; Stinchcomb, Audra L. In vitro/in vivo correlation of
transdermal naltrexone prodrugs in hairless guinea pigs. Pharmaceutical Research,
2005, 22(6), 981-989.
8. Paudel Kalpana S; Nalluri Buchi N; Hammell Dana C; Valiveti Satyanarayana;
Kiptoo Paul;
Hamad Mohamed O
; Crooks Peter A; Stinchcomb Audra L
Transdermal delivery of naltrexone and its active metabolite 6-β-naltrexol in
human skin in vitro and guinea pigs in vivo. Journal of Pharmaceutical Sciences,
2005, 94(9), 1965-1975.
9. Vaddi, Haranath K.;
Hamad, Mohamed O
.; Chen, Jianhong; Banks, Stan L.; Crooks,
Peter A.; Stinchcomb, Audra L. Human skin permeation of branched chain 3-O-alkyl-ester
and carbonate prodrugs of naltrexone. Pharmaceutical Research, 2005, 22(5), 758-765.
10. Hammell, D.C.; Stolarczyk, E.I.; Klausner, M.;
Hamad, M.O
.; Crooks, P.A.; Stinchcomb,
A.L. Bioconversion of naltrexone and its 3-O-alkyl-ester prodrugs in a human skin
equivalent. Journal of pharmaceutical sciences, 2005, 94(4), 828-836.
11. Satyanarayana Valiveti , Audra L. Stinchcomb, Dana C. Hammell, Kalpana S.
Paudel, ,
Mohamed Hamad
, Peter A. Crooks, , Audra L. Stinchcomb. In vivo
evaluation of 3-O-alkyl-ester transdermal prodrugs of naltrexone in hairless
guinea pigs. Journal of Controlled Release, 2005, 102(2):509-520.
12. Pillai, Omathanu;
Hamad, Mohamed
; Crooks, peter; Stinchcomb, Audra.
Physicochemical evaluation, in vitro human skin diffusion and concurrent