Dose/fractionation in particle
therapy of HCC
Abbrevia(ons: CPC = Child-Pugh classifica(on; PVTT = portal vein tumor thrombosis; PSPT
= passive sca@ering proton therapy; IVT = internal target volume based on 4D-CT; GI =
gastrointes(nal; PH = porta hepa(s; LPFS = local progression-free survival; LC = local
control; NR = not reported; OS = overall survival; G = toxicity grade;
Protons: 10-37 fractions
Carbon ions
HIT: 4 x 10 GyE
NIRS: 2 x 16-22.5 GyE