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Dose/fractionation in particle

therapy of HCC

Abbrevia(ons: CPC = Child-Pugh classifica(on; PVTT = portal vein tumor thrombosis; PSPT

= passive sca@ering proton therapy; IVT = internal target volume based on 4D-CT; GI =

gastrointes(nal; PH = porta hepa(s; LPFS = local progression-free survival; LC = local

control; NR = not reported; OS = overall survival; G = toxicity grade;

Protons: 10-37 fractions

Carbon ions

HIT: 4 x 10 GyE

NIRS: 2 x 16-22.5 GyE