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Biological uncertainties
A two-beam IMPT plan for brain tumor op6mized based on criteria
defined in terms of constant RBE of 1.1 (squares) and in terms of variable
RBE computed using a model published byWilkens, et al. (triangles). AKer
op6miza6on, both dose distribu6ons were converted to variable RBE-
weighted dose for comparison.
R. Mohan, D. Grosshans, Proton therapy – Present and future, Adv. Drug Deliv. Rev. (2016)
Over the last years 3 publications of
unexpected brain image alterations or
brain necrosis at presumably safe
Gy(RBE) levels in children undergoing
proton therapy for CNS tumors