1608-1609 / 2605
Carrie, JCO 2009
IQ DECLINE: HYPERFRACTIONATION
•
Standard risk medulloblastoma
•
48 patients – F-Up 77.7 months
•
Cr Spinal: 36 Gy+ 32 Gy boost (tumor bed)
• BID: 2x 1 Gy/d, 5 weekly sessions
• No chemotherapy
•
OS & DFS: 78% et 75% at 6 Y
•
2 points/Year IQ decline… only !
(Full, Verbal, P)