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Dose escalation

Dose Level (CIRT

GEM)

# of patients

43.2GyE

400mg/m2

6

43.2GyE

700mg/m2

6

43.2GyE

1000mg/m2

12

45.6GyE

1000mg/m2

6

48.0GyE

1000mg/m2

8

43.2-GyE in 12fr

GEM

400-1000mg/m2

OSE Week1 Week2 Week3

Carbon

Carbon

Carbon

G

G

G

↓ ↓ ↓ ↓

↓ ↓ ↓ ↓

↓ ↓ ↓ ↓