Dose escalation
Dose Level (CIRT
・
GEM)
# of patients
43.2GyE
・
400mg/m2
6
43.2GyE
・
700mg/m2
6
43.2GyE
・
1000mg/m2
12
45.6GyE
・
1000mg/m2
6
48.0GyE
・
1000mg/m2
8
43.2-GyE in 12fr
GEM
400-1000mg/m2
OSE Week1 Week2 Week3
Carbon
Carbon
Carbon
G
G
G
↓ ↓ ↓ ↓
↓ ↓ ↓ ↓
↓ ↓ ↓ ↓