Particle Therapy 2017

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RBE: dependence on biological endpoint

Krämer et al. 2003

Biological endpoint:

Clonogenic cell survival

Chinese ovary cells (CHO)

RBE = 5.4

50%

RBE = 4.2

10%

RBE = 3.4

1 %

What are the

underlying molecular

mechanisms that

cause the increase in

RBE

?